Coriolus Mushroom

Print

What is it?

Turkey tail (Coriolus versicolor) is a mushroom. It contains polysaccharide peptide (PSP) and polysaccharide krestin (PSK), which are used as medicine.

Turkey tail mushroom grows on stumps and the decomposing wood of trees. The PSP and PSK in turkey tail mushroom might help slow cancer growth and boost the immune system.

People use turkey tail mushroom to improve response to cancer medicines and radiation. It is also used for muscle strength, fatigue, UTIs, and many other conditions, but there is no good scientific evidence to support these uses.

It is effective?
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Possibly Effective for …

  • Cancer. Taking polysaccharide krestin (PSK), a substance found in turkey tail mushroom, by mouth might improve the response to chemotherapy by a small amount in some people with certain types of cancer.

There is interest in using turkey tail mushroom for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Is there concern for the safety of its use?
When taken by mouth: Turkey tail mushroom is likely safe for most people. For most healthy adults, it is well-tolerated. Some people who are receiving chemotherapy and a substance extracted from turkey tail mushroom called polysaccharide krestin (PSK) have reported nausea, vomiting, low white blood cell counts, and liver problems. But it is unclear if these side effects were due to the chemotherapy or PSK.

When used in the vagina: There isn’t enough reliable information to know if turkey tail mushroom is safe. It might cause side effects like itching and irritation.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn’t enough reliable information to know if turkey tail mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Are there any drug interactions?

Cyclophosphamide

Interaction Rating=Moderate Be cautious with this combination.

PSP, a chemical found in turkey tail mushroom, might change how quickly cyclophosphamide is removed from the body. This might alter how effective it is, and cause more side effects.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)

Interaction Rating=Minor Be watchful with this combination.

Some medications are changed and broken down by the liver. PSP, a chemical found in turkey tail mushroom, might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Turkey tail mushroom might lower blood sugar levels. Taking turkey tail mushroom along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Tamoxifen (Nolvadex)

Interaction Rating=Moderate Be cautious with this combination.

Taking turkey tail mushroom with tamoxifen might change the way that tamoxifen works in the body or reduce the effects of tamoxifen.

Are there any interactions with herbs and supplements?
Herbs and supplements that might lower blood sugar: Turkey tail mushroom might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.

Are there any interactions with food?
There are no known interactions with foods.

What dose is used?
Turkey tail mushroom contains polysaccharide krestin (PSK) and polysaccharide peptide (PSP). Some supplements contain just these chemicals, but the whole mushroom is also sometimes used. PSK has most often been used by adults in a dose of 3 grams by mouth daily for up to 36 months. Whole turkey tail mushroom has been used in a dose of 2.4 grams by mouth daily for up to 12 weeks. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

By what other names is the product known?
Bolet à Couleurs Variées, Bolet Versicolore, Boletus versicolor, Champignon Coriolus, Champignon de Queue de Dinde, Cloud Mushroom, Coriolus, Coriolus Mushroom, Coriolus versicolor, Hongo Coriolus, Kawaratake, Krestin, Polypore à Couleurs Variées, Polypore Versicolor, Polyporus Versicolor, Polysaccharide-K, Polysaccharide Krestin, Polysaccharide Peptide, Polysaccharopeptide, Polystictus versicolor, PSK, PSP, Trametes versicolor, Turkey Tail, Yun Chi, Yun Zhi, Yun-Zhi, Yunzhi.

Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.

© TRC Healthcare 2022. All rights reserved. Use and/or distribution is permitted only pursuant to a valid license or other permission from TRC Healthcare.