Together: Finding the Cures

Metastatic Breast Cancer Collaborative Research Initiative

Susan G. Komen + Duke University + University of North Carolina at Chapel Hill = REAL IMPACT

The Susan G. Komen® Metastatic Breast Cancer (MBC) Collaborative Research Initiative is a first-of-its-kind collaborative effort that is bringing together the best and brightest researchers at Duke Cancer Institute and UNC Lineberger Comprehensive Cancer Center to find breakthrough discoveries to end metastatic breast cancer. Research will cure this disease. Until then, research will transform MBC from a terminal diagnosis to a chronic disease, giving patients and their families the priceless gift of time.  

Thousands of families’ lives will be changed forever by an MBC diagnosis this year. Sadly, 44,000 lives are at risk this year. Families are waiting for us to find the cures. We need outstanding translational research into the understanding, detection, and treatment of metastatic breast cancer now. 

This is the work needed today. This is the work that will enable us to find the cures. The five-year relative survival rate for metastatic breast cancer is only 27%. This is unacceptable. With your help, Komen + Duke + UNC will help change those numbers and give the ultimate gift of time to the far too many families counting on us. 

Did You Know? 
Although metastatic breast cancer has spread to another part of the body, it’s still breast cancer and it is treated as breast cancer. 

Metastatic Breast Cancer (MBC)  is an advanced stage (stage IV) of breast cancer where tumor cells have spread to other parts of the body, such as the bones, liver, lungs, or brain. Nearly all breast cancer deaths are due to MBC. In fact, it kills over 44,000 women and men in the U.S. every year. It’s estimated there were more than 168,000 women living with metastatic breast cancer in the U.S. in 2020.  

The 5-year relative survival rate for women and men whose breast cancer is contained to the breast is 99%. Once breast cancer metastasizes to areas outside of the breast and surrounding regional lymph nodes—often spreading to the bones, liver, lungs, or brain—the 5-year relative survival rate drops to 27%.  

In the Triangle region of North Caroline, there is a unique opportunity to catalyze and support collaborations between two world-class cancer research institutions who share our mission to save lives from MBC.

Duke Cancer Institute and UNC Lineberger Comprehensive Cancer Center are partnering with Komen to build on the strong work currently being done at both institutions. There is no doubt that the need for translational research into the understanding, detection, and treatment of metastatic breast cancer is urgent.

This new Initiative is launching innovation and fast-tracking MBC research. By removing research silos and leveraging local expertise at both institutions, we will accelerate the discovery of ways for MBC patients to live well and live longer with this disease.  In fact, over 125 researchers and advocates from UNC/Duke participated in an MBC Collaborative Research Summit hosted by Komen in the spring of 2021, an event that inspired ideas and new collaborations within and across institutions.

“We’ve developed a much deeper understanding of the genomics and cellular changes that lead to metastatic breast cancer. We’ve made some important strides in extending life for our patients but now is the time to do more. The Komen MBC Collaborative Research Initiative, linking the amazing clinical and research talent at UNC and Duke, is a bold move that will ignite collaboration and yield more effective therapy for Triangle residents and the nation.”
– Dr. Shelley Earp, UNC Lineberger Cancer Center

“Despite many advances in the diagnosis and treatment of cancer in recent years, metastatic breast cancer remains a disease that kills too many women. New treatment approaches are still desperately needed, and success will require collaborations across disciplines and institutions. The Komen MBC Collaborative Research Initiative recognized this need and is responding by providing support for collaborations between investigators at Duke University and UNC-Chapel Hill. Working together, all things become possible.”
– Dr. Michael Kastan, Duke Cancer Institute

“I call myself a thriver because I AM thriving. I live my life and THRIVE, but my family and I know that it is RESEARCH that will save my life.”
– Stephanie Walker, MBC Thriver and Advocate – Tarboro, NC 

The Komen MBC Collaborative Research Initiative is a unique, national program with a local focus that leverages and builds upon current, Triangle-based research. Komen Scholars and other world-class investigators, early career researchers who represent the next generation of research leaders, and patient advocates at Duke and UNC have shown great enthusiasm for producing real impact through true intellectual collaboration. Continued funding must be sustained to make this revolutionary lifesaving research possible. 

In the spring of 2021 Komen, through its highly regarded Research Program, released its first request for MBC Collaborative Research Grant proposals. Only collaborative projects between Duke Cancer Institute and UNC Lineberger Comprehensive Cancer Center are eligible for these grants.  In response to this initial request Komen received 9 innovative proposals from teams of researchers at Duke/UNC who want to find much-needed breakthroughs for MBC. 

Proposals will be evaluated through Komen’s highly esteemed peer-review process which is guided by the Komen Scientific Advisory Board, managed by our PhD level and professional staff, and involves our Komen Scholars, other scientific experts, and MBC patient advocates. With this rigorous review and through a true global lens, the Initiative will drive the most critical research needs for MBC. 

SEED Donor
Jean S. Gross and Donald J. Miller

Susan G. Komen® will award its first MBC Collaborative Research Grants in October 2021 to support collaborative research projects led by researchers at Duke University and the University of North at Carolina at Chapel Hill.  The goal of these grants is to address significant gaps in our knowledge about metastatic breast cancer (MBC) to advance MBC patient care and improve patient outcomes. Additionally, these grants will foster a collaborative research environment between two highly resourced academic research centers to synergize the independent research efforts of their talented faculty and staff to drive discoveries that will allow metastatic breast cancer patients to live longer, better lives.   

Blue Cross and Blue Shield of North Carolina (Blue Cross NC) invested $500,000 in the first year to fund grants for researchers at both Duke Cancer Institute and the University of North Carolina Lineberger Comprehensive Cancer Center for the purpose of collaborating on research into the tragic disparities in mortality between Black women living with stage IV, metastatic breast cancer (MBC), and their white counterparts.

Other critical areas of focus include:
• How can the evolution of drug resistance be monitored and defeated? 
• Does the immune system impact breast cancer development and treatment?  
• How does the tumor microenvironment influence metastases? 
• Will liquid biopsies or other technologies lead to early detection of late recurrence? 

Thank You to Our Generous Donors

SEED DONOR

Jean S. Gross & Donald J. Miller

LEADERSHIP DONOR

Blue Cross and Blue Shield of North Carolina


CATALYST DONOR – $66,333

A Sole Team for Vickie
Friends of Vickie Grabowski

DIAMOND DONORS – $30,000-$59,999

Lisa Carey, MD, FASCO
Biologics by McKesson

PLATINUM DONORS – $20,000-$29,999

Donald McDonnell, PhD

GOLD DONORS – $10,000-$19,999

Dennis Grabowski
on behalf of A Sole Team For Vickie

Phil & Sandy Byrd
on behalf of A Sole Team For Vickie

Robert & Judy McDevitt

SILVER DONORS – $5,000-$9,999

Terry Clark
Barbara McGuire in Honor of Peggy Fain
Dena Silver
Chris & Missy VanLokeren

BRONZE DONORS – $1,000-$4,999

Donna Anderson
Lyn Andrews
Anonymous
Rose Auman
in honor of Pam Kohl
Tom Blue
Mark Boomgarden
Margaret Brown
Capital Pest Services, Inc.
Byron Creech
Partha Daughtridge
Jennifer Ead
Louisa and Beau Fisher
Jill & RolandGammon
Stephanie Humrickhouse
Diane Jewell
Joanna Johnson
Pam Kohl & Tom Gongaware
Kimberlin Kincaid
Mary Moss
Fara Palumbo
Dr. Charles Perou
Mitch Perry
Meg Revelle
Karen Rice
Savannah Community Foundation
Robert Silver
Kathi Sippen
Amanda Smith
Stephen Solomon
James Stone
Cantey Tanner
Tomika Vasey and Nicholas Caspero Family Foundation
Lynda Weatherby
Dr. Danielle Wellman
Carole & Brad Wilson
Debbie Woody

We must do everything we can to save lives.

Because 44,000 deaths each year from MBC is unacceptable. 

Ending MBC starts with you and your bold investment in the Komen Metastatic Breast Cancer Collaborative Research Initiative. Research is hope for those fighting metastatic breast cancer today, and for those who will be diagnosed tomorrow.  

Enough is enough. We must do everything we can to save lives. And, TOGETHER, we will. 

Join us in supporting this lifesaving research by making a bold investment today! 

SEED Donor
Jean S. Gross and Donald J. Miller

quote_icon

Victoria Wolodzko
Senior VP, Mission at Susan G. Komen

“Today, the five-year relative survival rate for metastatic breast cancer is only twenty-seven percent. There is critical need for increasing our understanding of metastatic breast cancer and developing new ways to treat those living with the disease to help them live longer, better lives. 

We have a unique opportunity to support innovative research in the Triangle area through a unique collaboration between Duke University and the University of North Carolina at Chapel Hill. This approach can lead to the very breakthroughs needed to change outcomes and save lives. 

We are inspired by the leadership of the Komen NC Triangle to develop and lead this game-changing initiative, and we look forward to working alongside this local collaboration to find new treatments and cures for metastatic breast cancer.” 

Our Partners

The Metastatic Breast Cancer Collaborative Research Initiative is dedicated to funding research breakthroughs specifically for metastatic breast cancer in the labs of two of the most renowned research institutions in the world – The University of North Carolina at Chapel Hill and Duke University. Over the past 10 years, Susan G. Komen has invested more than $27 million in Triangle-based research.

Diamond Sponsor
MBC Research Virtual Summit Sponsor

Spotlight Catalyst Donor
A Sole Team for Vickie

SEED Donor
Jean S. Gross and Donald J. Miller

Make a BOLD investment. Donate today.