Hyperplasia and Other Benign Breast Conditions
Benign breast conditions (also called benign breast diseases) are non-cancerous breast disorders.
Some of these conditions are linked to an increased risk of breast cancer and others are not.
To assess breast cancer risk, benign breast conditions are classified as:
- Proliferative (those with quickly growing cells)
- Non-proliferative (those without quickly growing cells)
Proliferative breast conditions
Proliferative breast conditions are not cancerous, but they are linked to an increased risk of breast cancer [183-186].
The most common proliferative breast condition is hyperplasia.
There are 2 types of hyperplasia: usual hyperplasia (more common) and atypical hyperplasia (less common).
In usual hyperplasia (the most common form of hyperplasia), the proliferating (dividing) cells look normal under a microscope.
Women with usual hyperplasia have about twice the breast cancer risk of women without a proliferative breast condition [183-184].
For a summary of research studies on usual hyperplasia and breast cancer, visit the Breast Cancer Research Studies section.
In atypical hyperplasia, the proliferating (dividing) cells look abnormal.
Atypical hyperplasia is less common than usual hyperplasia.
Women with atypical hyperplasia have about 3-5 times the breast cancer risk of women without a proliferative breast condition [183-186].
One study found women with atypical hyperplasia had about a 29 percent chance of developing breast cancer within 25 years .
For a summary of research studies on atypical hyperplasia and breast cancer, visit the Breast Cancer Research Studies section.
Breast cancer screening for women with atypical hyperplasia
For women with atypical hyperplasia who also have a greater than 20 percent lifetime risk of invasive breast cancer, there are special breast cancer screening recommendations. (Estimate your lifetime risk or learn more about risk.)
- Have a mammogram every year, starting at age 30 (3D mammography (breast tomosynthesis) may be considered)
- Have a clinical breast exam every 6-12 months
- Talk with a health care provider about screening with breast MRI every year, starting at age 25
This medical care helps ensure if breast cancer does develop, it’s caught early when the chances of survival are highest.
The NCCN recommends women with atypical hyperplasia who have a less than 20 percent lifetime risk of invasive breast cancer and women with usual hyperplasia get the same breast cancer screening as women at average risk.
Learn more about breast cancer screening for women at higher risk.
Risk reduction for women with atypical hyperplasia
The NCCN strongly recommends women with atypical hyperplasia (but not usual hyperplasia) take a risk-lowering drug (such as tamoxifen) to lower their risk of developing breast cancer .
These drugs can lower the risk of breast cancer in women with atypical hyperplasia by about 86 percent .
Learn more about risk-lowering drugs.
Non-proliferative breast conditions
Non-proliferative breast conditions (such as cysts) are not linked to an increased risk of breast cancer.
Learn more about benign breast conditions.