Hydrazine sulfate

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What is it?

Hydrazine sulfate is a chemical used in industry and as jet fuel. Some people use it as medicine.

Hydrazine sulfate is used for many types of cancer. It is also used for involuntary weight loss in people with cancer (cachexia or wasting syndrome), but there is no good scientific evidence to support these uses. Using hydrazine sulfate may also be unsafe.

It is effective?
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Possibly Ineffective for …

  • Colon and rectal cancer. Taking hydrazine sulfate by mouth does not improve the health of people who have colorectal cancer that has spread throughout the body (metastasized).
  • Cancer. Research shows that hydrazine sulfate is ineffective for treating ovarian cancer, colorectal cancer, breast cancer, lung cancer, pancreatic cancer, cervical cancer, prostate cancer, uterine cancer, melanoma, and other kinds of cancer.

Probably Ineffective for …

  • Lung cancer. Adding hydrazine sulfate to chemotherapy does not improve quality of life, tumor response, weight gain, or survival in most people with a type of lung cancer called non-small-cell lung cancer.

Insufficient Evidence to Make a Determination for …

  • Brain tumor. Taking hydrazine sulfate along with chemotherapy may improve nerve-related symptoms in people with brain cancer. It may also help reduce the size of tumors in people with a specific type of brain cancer called glioblastoma.
  • Involuntary weight loss in people who are very ill (cachexia or wasting syndrome). Early research shows that hydrazine sulfate might slow weight loss in some cancer patients.
  • Cancer that starts in white blood cells (Hodgkin lymphoma). Early research shows that hydrazine sulfate might slow the progress of advanced Hodgkin lymphoma.
  • Nerve cancer (neuroblastoma). Early research shows that hydrazine sulfate might prevent the growth of neuroblastoma.
  • Other conditions.

More evidence is needed to rate the effectiveness of hydrazine sulfate for these uses.

How does it work?
Hydrazine sulfate may block certain chemical reactions in the body that can lead to malnutrition and muscle wasting.

Is there concern for the safety of its use?
When taken by mouth: Hydrazine sulfate is POSSIBLY UNSAFE. It has been linked to cases of liver damage, seizure, coma, and death. Other side effects include nausea, vomiting, dizziness, drowsiness, nerve problems, violent behavior, restlessness, confusion, excitement, weakness, irregular breathing, abnormal blood sugar levels, rash, and kidney damage.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hydrazine sulfate is POSSIBLY UNSAFE for anyone, including pregnant and breast-feeding women. It has been linked to cases of liver damage, seizure, coma, and death.

Diabetes: Hydrazine sulfate might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use hydrazine sulfate.

Liver disease: Hydrazine sulfate might damage the liver. It might be unsafe for people with liver disease.

Surgery: Since hydrazine sulfate might affect blood glucose levels, there is a concern that it might interfere with blood glucose control during and after surgery. Stop using hydrazine sulfate at least 2 weeks before a scheduled surgery.

Are there any drug interactions?

Isoniazid (INH, Nydrazid)

Interaction Rating=Moderate Be cautious with this combination.

Isoniazid is a drug used for tuberculosis. The body breaks isoniazid down to hydrazine. Using both isoniazid and hydrazine might increase the risk of liver damage.

Medications for depression (MAOIs)

Interaction Rating=Major Do not take this combination.

Hydrazine sulfate contains a chemical that affects the body. This chemical might increase the side effects of some medications used for depression.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Hydrazine sulfate might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking hydrazine sulfate along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Sedative medications (CNS depressants)

Interaction Rating=Major Do not take this combination.

Hydrazine sulfate might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hydrazine sulfate along with sedative medications might cause too much sleepiness.
Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Are there any interactions with herbs and supplements?
Herbs and supplements that might lower blood sugar: There is some evidence that hydrazine sulfate might lower blood sugar. Using it with other herbs or supplements that have this same effect might cause blood sugar to drop too low. Some of these products include bitter melon, cowhage, ginger, goat’s rue, fenugreek, kudzu, willow bark, and others.

Are there any interactions with food?
Tyramine-containing foods: Avoid using hydrazine sulfate with foods that contain a chemical called tyramine. Tyramine-containing foods include avocado, banana, brewer’s yeast, broad beans, caviar, aged cheese, aged red wine, herring, liver, and pickled meats.

What dose is used?
The appropriate dose of hydrazine sulfate depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hydrazine sulfate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

By what other names is the product known?
Segidrin, Sehydrin, Sulfate d’Hydrazine, Sulfato de Hidracina.

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