The Who, What, Where, When and Sometimes, Why.

Hydrazine sulfate

Hydrazine sulfate

What is it?

Hydrazine sulfate is a chemical used in industry and as jet fuel. Some people use it as medicine.

Hydrazine sulfate is used for treating colon and rectal (colorectal) cancer, lung cancer, brain cancer (neuroblastoma), Hodgkin’s disease (lymph cancer), and other cancers. It is also used for the general weight loss and wasting (cachexia) associated with cancer.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for HYDRAZINE SULFATE are as follows:

Possibly Ineffective for…

  • Colon and rectal cancer that has spread (metastatic colorectal cancer). Taking hydrazine sulfate by mouth does not improve metastatic colorectal cancer.
  • Cancer. There is some evidence that hydrazine sulfate is ineffective for treating ovarian cancer, colorectal cancer, breast cancer, lung cancer, pancreatic cancer, cervical cancer, prostate cancer, uterine cancer, melanoma, and other kinds of cancer.

Likely Ineffective for…

  • Lung cancer. Adding hydrazine sulfate to chemotherapy doesn’t significantly improve quality of life, tumor response, weight gain, or survival in most people with a type of lung cancer called non-small-cell lung cancer.

Insufficient Evidence to Rate Effectiveness for…

  • Brain tumor: Taking hydrazine sulfate along with chemotherapy may improve nerve-related symptoms in people with brain cancer. It may also help reduce the size of tumors in people with a specific type of brain cancer called glioblastoma.
  • General weight loss and wasting associated with cancer. Early research suggests that hydrazine sulfate might slow weight loss in some cancer patients.
  • Hodgkin’s disease (lymph cancer). Some research suggests that hydrazine sulfate might slow the progress of advanced Hodgkin’s disease.
  • Nerve cancer (neuroblastoma). There is some evidence that hydrazine sulfate might prevent the growth of neuroblastoma.
  • Other conditions.

More evidence is needed to rate the effectiveness of hydrazine sulfate for these uses.

Hydrazine sulfate may block chemical reactions in the body that might lead to malnutrition and muscle wasting associated with cancer.

Hydrazine sulfate is POSSIBLY UNSAFE. It has been linked to cases of liver damage, seizure, coma, and death.

Hydrazine sulfate can cause some side effects including nausea, vomiting, dizziness, drowsiness, nerve problems, violent behavior, restlessness, seizures, coma, confusion, mood stimulation, excitement, weakness, irregular breathing, abnormal blood sugar levels, rash, and kidney damage.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hydrazine sulfate is POSSIBLY UNSAFE for anyone, including pregnant and breast-feeding women. It has been linked to cases of liver damage, seizure, coma, and death.

Diabetes: Hydrazine sulfate might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use hydrazine sulfate.

Liver disease: Hydrazine sulfate might damage the liver. It might be unsafe for people with liver disease.

Surgery: Since hydrazine sulfate might to affect blood glucose levels, there is a concern that it might interfere with blood glucose control during and after surgery. Stop using hydrazine sulfate at least 2 weeks before a scheduled surgery.

Isoniazid (INH, Nydrazid)

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Isoniazid is a drug used for tuberculosis. The body breaks isoniazid down to hydrazine. Using both isoniazid and hydrazine might increase the risk of liver damage.

Medications for depression (MAOIs)

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate contains a chemical that affects the body. This chemical might increase the side effects of some medications used for depression.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Medications for diabetes (Antidiabetes drugs)

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking hydrazine sulfate along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Sedative medications (CNS depressants)

Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hydrazine sulfate along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Herbs and supplements that might lower blood sugar.

There is some evidence that hydrazine sulfate might lower blood sugar. Using it with other herbs or supplements that have this same effect might cause blood sugar to drop too low. Some of these products include bitter melon, cowhage, ginger, goat’s rue, fenugreek, kudzu, willow bark, and others.

Pyridoxine (Vitamin B6)

Hydrazine might interfere with the way pyridoxine works in the body.

Tyramine-containing foods

Avoid using hydrazine sulfate with foods that contain a chemical called tyramine. Tyramine-containing foods include avocado, banana, brewer’s yeast, broad beans, caviar, aged cheese, aged red wine, herring, liver, and pickled meats.

The appropriate dose of hydrazine sulfate depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hydrazine sulfate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Sehydrin, Sulfate d’Hydrazine, Sulfato de Hidracina.


Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.

For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.

© Copyright 1995-2019. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber’s Letter, and Pharmacist’s Letter. All rights reserved.
PH (209) 472-2244



Discover the different ways you can help

Get Involved


1-877 GO KOMEN

In Your Own Words

Give hope to others in your situation

Share Your Story or Read Others