The Who, What, Where, When and Sometimes, Why.

Fine Needle Aspiration (Fine Needle Biopsy)

Fine needle aspiration (also known as fine needle biopsy) removes cells from a suspicious lump in the breast. The needle used is thinner than in core needle biopsy.

Fine needle aspiration is only used for lumps that can be felt (palpable masses).

Although core needle biopsy is usually the first choice for palpable masses, fine needle aspiration is sometimes done as a quick way to sample a breast lump felt during a clinical breast exam.

The procedure

A fine needle aspiration can be done in your health care provider’s office.

Before the procedure, your provider may use a small amount of local anesthetic to numb the area.

Your provider will then insert the needle and remove a sample of cells.

The whole process only takes a few minutes.

Advantages of fine needle aspiration

Fine needle aspiration is accurate when done by an experienced health care provider and read by an experienced cytopathologist (a physician who specializes in checking cells under a microscope).

The procedure is less invasive than a core needle biopsy and the chance of infection or bruising is very small.

Drawbacks of fine needle aspiration

One drawback of fine needle aspiration is the needle can miss a tumor and take a sample of normal cells instead.

If this happens, the biopsy will show cancer doesn’t exist when in fact, it does. This is called a false negative result and delays diagnosis. The false negative rate of fine needle aspirations of lumps that can be felt is low, about 2-4 percent [7,10-11].

Sometimes, even if the correct area is sampled, not enough cells are removed to be able to tell if there’s cancer. So, a fine needle aspiration that doesn’t find cancer may need to be followed up with a core needle biopsy or a surgical biopsy.

Another drawback of fine needle aspiration is the cell samples give limited information about the tumor. For example, they often can’t tell whether a tumor is non-invasive breast cancer (ductal carcinoma in situ) or invasive breast cancer.

The cells removed by fine needle aspiration must also be checked by an experienced breast cytopathologist, and not all hospitals have one. 

Updated 12/12/20


Fact Sheet

Fact Sheet