The Who, What, Where, When and Sometimes, Why.

Menopausal hormone therapy and breast cancer recurrence

This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. However, to get the most out of the tables, it’s important to understand some key concepts. Learn how to read a research table.

Introduction: Menopausal hormone therapy (MHT) isn’t usually given to women who’ve had breast cancer because findings from large randomized controlled trials have shown MHT use increases the risk of [1-2]:

  • Breast cancer recurrence at the original site (local recurrence)
  • Metastasis (distant recurrence)
  • Cancer in the opposite breast  

MHT is also known as postmenopausal hormone therapy and hormone replacement therapy.

Women have other options for treating menopausal symptoms.

Learn about MHT and breast cancer risk.

Learn about the strengths and weaknesses of different types of studies.  

Study selection criteria: Randomized controlled trials and meta-analyses.

Table note: Relative risk above 1 indicates increased risk. Relative risk below 1 indicates decreased risk.

Study

Study Population
(number of participants)

Follow-up
(months)

Relative Risk of a Breast Cancer Recurrence Among Women Who Used MHT after Breast Cancer Compared to Those Who Did Not,
RR (95% CI)

Randomized controlled trials

Holmberg et al. [1]

442

48

Local recurrence, metastasis or
cancer in the opposite breast:
2.2 (1.0-5.1)

Fahlén et al. [2]

378

130

Local recurrence:
0.8 (0.3-1.7)

Metastasis:
1.0 (0.5-2.3)

Cancer in the opposite breast:
3.3 (1.2-10.9)

Meta-analyses

Mudhune et al. [3]

4
randomized controlled trials

Local recurrence, metastasis or
cancer in the opposite breast:
1.46 (1.20-1.77)

 

References

  1. Holmberg L, Iverson OE, Rudenstam CM, et al., for the HABITS Study Group. Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. J Natl Cancer Inst. 100(7):475-82, 2008.
  2. Fahlén M, Fornander T, Johansson H, et al. Hormone replacement therapy after breast cancer: 10 year follow up of the Stockholm randomised trial. Eur J Cancer. 49(1):52-9, 2013.
  3. Mudhune GH, Armour M, McBride KA. Safety of menopausal hormone therapy in breast cancer survivors older than fifty at diagnosis: a systematic review and meta-analysis. Breast. 47:43-55, 2019.

Updated 03/15/21

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