Vitamin E

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What is it?

Vitamin E is a vitamin that dissolves in fat. It is found in many foods including vegetable oils, cereals, meat, poultry, eggs, fruits, vegetables, and wheat germ oil. It is also available as a supplement.

Vitamin E is used for treating vitamin E deficiency, which is rare, but can occur in people with certain genetic disorders and in very low-weight premature infants. Vitamin E is also used for many other conditions, but there is no good scientific evidence to support these other uses.

The American Heart Association recommends obtaining antioxidants, including vitamin E, by eating a well-balanced diet high in fruits, vegetables, and whole grains rather than from supplements until more is known about the risks and benefits of taking supplements.

A type of vitamin E called vitamin E acetate is an ingredient in some vaping products. Using vaping products containing vitamin E acetate has been linked to serious lung injury.

It is effective?
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Effective for …

  • An inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED). The genetic movement disorder called ataxia causes severe vitamin E deficiency. Vitamin E supplements are used as part of the treatment for ataxia.
  • Vitamin E deficiency. Taking vitamin E by mouth is effective for preventing and treating vitamin E deficiency.

Possibly Effective for …

  • Alzheimer disease. Taking vitamin E supplements doesn’t seem to prevent Alzheimer disease from developing. However, in people who already have Alzheimer disease, taking vitamin E along with some anti-Alzheimer medicines might slow down the worsening of memory loss. Vitamin E might also delay the loss of independence and the need for caregiver assistance in people with mild-to-moderate Alzheimer disease.
  • A blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia). Taking vitamin E by mouth seems to benefit children with the blood disorder called beta-thalassemia.
  • Menstrual cramps (dysmenorrhea). Taking vitamin E for 2 days before bleeding and for 3 days after bleeding starts seems to decrease pain and reduce menstrual blood loss. Taking vitamin E with fish oil might provide even more pain relief than taking vitamin E alone.
  • An inherited disorder that causes red blood cells to break down in response to stress (G6PD deficiency). Some research shows that taking vitamin E by mouth, alone or together with selenium, might benefit people with an inherited disorder called G6PD deficiency.
  • Bleeding within the skull (intracranial hemorrhage). Taking vitamin E by mouth seems to be effective for treating bleeding in the skull in premature infants.
  • Bleeding into or around the fluid-filled areas (ventricles) of the brain (intraventricular hemorrhage). Some research shows that giving vitamin E by mouth to premature infants can reduce the risk for bleeding into the brain. But giving high doses of vitamin E might increase the risk for a serious blood infection (sepsis) in these infants.
  • Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). Taking vitamin E by mouth improves pregnancy rates for men with fertility problems. But taking high doses of vitamin E together with vitamin C doesn’t seem to provide the same benefits.
  • Reduced benefit of nitrate therapy that happens when nitrates are used all day (nitrate tolerance). There is some evidence that taking vitamin E daily can help prevent nitrate tolerance.
  • Swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (nonalcoholic steatohepatitis or NASH). Taking vitamin E daily seems to improve inflammation and liver markers of this form of liver disease in adults and children.
  • Premenstrual syndrome (PMS). Taking vitamin E by mouth seems to reduce anxiety, craving, and depression in some women with PMS.
  • A movement disorder often caused by antipsychotic drugs (tardive dyskinesia). Taking vitamin E by mouth seems to improve symptoms associated with the movement disorder called tardive dyskinesia. However, some other research suggests that it doesn’t improve symptoms, but may prevent symptoms from worsening.

Possibly Ineffective for …

  • An eye disease that leads to vision loss in older adults (age-related macular degeneration or AMD). Most research suggests that taking vitamin E, alone or along with other antioxidants, isn’t effective for preventing or treating age-related vision loss.
  • Lou Gehrig’s disease (amyotrophic lateral sclerosis or ALS). Research suggests that taking vitamin E (alpha-tocopherol) along with conventional medication doesn’t affect function or increase survival rates compared to conventional medication alone in people with Lou Gehrig’s disease.
  • Chest pain (angina). Taking vitamin E by mouth might have some effect on the functioning of blood vessels, but it doesn’t appear to reduce chest pain.
  • Hardening of the arteries (atherosclerosis). Taking vitamin E (RRR-alpha-tocopherol) by mouth doesn’t appear to prevent the progression of atherosclerosis. However, there is some early evidence that taking vitamin E and vitamin C might help prevent the progression of atherosclerosis in men.
  • Eczema (atopic dermatitis). Research suggests that taking vitamin E, alone or along with selenium, doesn’t improve symptoms of eczema.
  • Hot flashes in people treated for breast cancer. Taking vitamin E by mouth doesn’t seem to reduce hot flashes in women who have had breast cancer.
  • A lung disease that affects newborns (bronchopulmonary dysplasia). Taking vitamin E by mouth doesn’t seem to reduce an infant’s risk for developing a lung disease called bronchopulmonary dysplasia.
  • Cancer. Taking a combination of vitamin E, vitamin C, beta carotene, selenium, and zinc doesn’t seem to lower overall cancer risk. However, it might reduce the risk of cancer in men, although evidence is conflicting.
  • Cataracts. Most research shows that taking vitamin E doesn’t prevent cataracts.
  • Nerve damage in the hands and feet caused by cancer drug treatment. Research shows that taking vitamin E before and after treatment with certain cancer drugs does not reduce the risk of nerve damage.
  • Colon cancer, rectal cancer. Most evidence suggests that taking vitamin E doesn’t prevent the occurrence of colon cancer or rectal cancer or the development of non-cancerous colorectal tumors, which are considered precursors to colon cancer.
  • Heart failure and fluid build up in the body (congestive heart failure or CHF). Taking vitamin E by mouth for 12 weeks doesn’t seem to improve heart function in people with CHF and doesn’t decrease the chance of developing CHF.
  • Head and neck cancer. Taking vitamin E (all-rac-alpha-tocopherol) daily during radiation therapy and for 3 years after the end of therapy doesn’t seem to reduce the risk of head and neck cancer recurrence. There is some concern that taking vitamin E might actually increase the risk of tumor recurrence. People with head and neck cancer should avoid daily vitamin E supplements in doses over 400 IU daily.
  • High blood pressure. Taking vitamin E by mouth doesn’t seem to lower blood pressure in people already taking blood pressure medications.
  • Infants with birth weight below the 10th percentile due to inadequate nutrition. Some research shows that taking vitamin E throughout pregnancy does not lower the risk of having a baby with a low birth weight because of inadequate nutrition while in the womb.
  • Liver disease. Taking vitamin E doesn’t reduce the risk of death in people with liver disease.
  • White patches inside the mouth that are usually caused by smoking (oral leukoplakia). Most research shows that taking vitamin E for up to 7 years doesn’t reduce the risk for mouth sores in men who smoke.
  • Osteoarthritis. Taking vitamin E doesn’t seem to decrease pain or stiffness in people with osteoarthritis. Vitamin E also doesn’t seem to prevent the condition from becoming worse.
  • Pancreatic cancer. Taking vitamin E, alone or together with other antioxidants such as beta-carotene and vitamin C, doesn’t seem to reduce the risk of developing pancreatic cancer.
  • A type of throat cancer (pharyngeal cancer). Taking vitamin E by mouth doesn’t seem to reduce the risk of mouth or pharyngeal cancer in people with diabetes.
  • A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). Most evidence shows that taking vitamins E and C doesn’t reduce the risk of high blood pressure during pregnancy.
  • Preterm birth. Research shows that taking vitamin E during pregnancy does not lower the risk for preterm birth.
  • Prostate cancer. Most research suggests that taking vitamin E supplements doesn’t reduce the risk of developing prostate cancer, and might actually increase the risk.
  • Infection of the airways. Taking vitamin E by mouth, alone or as a multivitamin, doesn’t seem to help prevent respiratory tract infections. It also doesn’t seem to lessen symptoms once an infection develops.
  • An inherited eye condition that causes poor night vision and loss of side vision (retinitis pigmentosa). Taking vitamin E by mouth doesn’t appear to slow vision loss, and might actually increase vision loss, in people with a condition called retinitis pigmentosa.
  • An eye disorder in premature infants that can lead to blindness (retinopathy of prematurity). Research shows that giving vitamin E to premature infants does not lower the risk for retinopathy. High doses of vitamin E might also increase the risk for a serious blood infection (sepsis) in these infants.
  • Scarring. Applying vitamin E to the skin doesn’t seem to reduce scarring after surgery.
  • Stillbirth. Some research shows that taking vitamin E throughout pregnancy does not lower the risk of stillbirth.

Probably Ineffective for …

  • Non-cancerous breast disorders. Taking vitamin E supplements doesn’t help treat non-cancerous breast disorders, also known as benign breast disease.
  • Breast cancer. Although having higher blood levels of vitamin E might be linked with a reduced risk of breast cancer, increasing vitamin E intake from the diet or supplements doesn’t reduce the risk of developing breast cancer.
  • Heart disease. Vitamin E doesn’t prevent heart disease in healthy people or those at risk. It also doesn’t seem to prevent stroke or heart attack in people with heart disease.
  • Death of an unborn or premature baby. Vitamin E given to preterm infants doesn’t seem to reduce the risk of death in the infant.
  • Lung cancer. Taking man-made vitamin E for up to 8 years doesn’t reduce the risk of developing lung cancer in men who smoke. Taking natural vitamin E for up to 10 years also doesn’t prevent lung cancer or reduce the risk of death from lung cancer.
  • Death from any cause. Research suggests that taking vitamin E for at least 1 year doesn’t reduce the risk of death from any cause.
  • Growth and development in premature infants. Vitamin E doesn’t seem to prevent or treat anemia in preterm infants.

Insufficient Evidence to Make a Determination for …

  • Low levels of red blood cells in people with long-term illness (anemia of chronic disease). Some research shows that that taking vitamin E improves the response to drug therapy for anemia in adults and children on hemodialysis.
  • Asthma. The role of vitamin E in asthma is unclear. While some research suggests that vitamin E prevents the risk of asthma and improves breathing in children, other research doesn’t show this effect.
  • Prone to allergies and allergic reactions (atopic disease). Taking vitamin E supplements during pregnancy doesn’t seem to decrease the chance of infants having eczema, food allergy, wheeze, or any allergic disease later in life.
  • Bladder cancer. Some research shows that consuming large amounts of vitamin E for at least 10 years might reduce the risk for bladder cancer. But it’s unclear how much vitamin E might be needed to reduce this risk. It’s also unknown if this benefit comes from eating vitamin E in the diet or taking vitamin E supplements.
  • Burns. Early research suggests that vitamin E applied to the skin might improve burn wound healing and reduce infection.
  • Infections in people treated with cancer drugs. Research suggests that higher intake of vitamin E in the diet might reduce the risk of infection in children treated with cancer drugs.
  • Hearing loss caused by the drug cisplatin. Early research shows that vitamin E seems to reduce hearing loss caused by cisplatin.
  • Kidney damage caused by contrast dyes (contrast induced nephropathy). Some research shows that vitamin E injected into the vein doesn’t decrease risk of kidney damage caused by injected dyes. However, other research shows that taking vitamin E by mouth decreases the risk of kidney damage from the same dyes.
  • Diseases, such as Alzheimer disease, that interfere with thinking (dementia). Some research suggests that men who consume vitamin E and vitamin C have a decreased risk of developing some types of dementia. But taking vitamin E supplements doesn’t seem to prevent dementia.
  • Diabetes. Getting more vitamin E from the diet is linked to a lower risk of getting diabetes. However, vitamin E doesn’t improve blood sugar in most people who already have type 2 diabetes. It only seems to lower blood sugar in people with type 2 diabetes who also have low blood levels of vitamin E. Additionally, vitamin E might improve blood sugar control in people with type 1 diabetes.
  • Kidney damage in people with diabetes (diabetic nephropathy). Early research shows that taking vitamin E might improve kidney function by a small amount in people with this condition.
  • Nerve pain in people with diabetes (diabetic neuropathy). Early research suggests that vitamin E may help relieve diabetic nerve pain.
  • Down syndrome. Early research shows that vitamin E doesn’t improve mental ability in people over 50 with Down syndrome.
  • Stomach cancer. Taking vitamin E plus beta-carotene and/or vitamin C doesn’t seem to prevent stomach cancer. But there is some evidence that consuming more vitamin E from the diet might decrease the risk slow the progression of stomach cancer.
  • Scarring or hardening of blood vessels in the kidney (glomerulosclerosis). Taking vitamin E by mouth might improve kidney function in children with this condition.
  • An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). Natural vitamin E (RRR-alpha-tocopherol) can improve symptoms in people with early Huntington disease. But it doesn’t seem to help people with more advanced disease.
  • A condition that slowly leads to kidney disease (IgA nephropathy). Early research suggests that taking vitamin E can improve kidney function in children with a kidney disease called IgA nephropathy.
  • Inability to become pregnant within a year of trying to conceive (infertility). Early research shows that taking vitamin E can improve some measures in women who have trouble getting pregnant through in vitro fertilization (IVF). But it’s not clear if vitamin E improves the chance of having a successful pregnancy.
  • Leg pain during exercise due to poor blood flow (intermittent claudication). Taking all-rac-alpha-tocopherol (synthetic vitamin E) alone or together with beta-carotene by mouth doesn’t appear to improve poor blood flow in the legs. However, other research suggests that taking vitamin E daily for 18 months reduces symptoms of intermittent claudication.
  • Lice. Early research suggests that using vitamin E spray (LiceKO) is more effective for removing head lice compared to permethrin rinse (Lyclear creme rinse).
  • Liver transplant. Taking vitamin E (tocopheryl succinate polyethylene glycol) might reduce the dose of immunosuppressant needed after a liver transplant.
  • The most serious type of skin cancer (melanoma). Some evidence suggests that taking vitamin E (RR-alpha-tocopherol) daily doesn’t reduce the risk of developing skin cancer.
  • Symptoms of menopause. Early evidence suggests that vitamin E might reduce hot flashes in women after menopause.
  • Toxicity caused by the drug methotrexate. It is unclear if vitamin E reduces liver damage from methotrexate.
  • Leg cramps that occur at night. Early evidence suggests that vitamin E might reduce nighttime leg cramps. However, other evidence suggests otherwise.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). There is not enough evidence to know if vitamin E can help people with NAFLD. Some early research shows that vitamin E might improve markers of liver injury, reduce inflammation (swelling), and prevent the build-up of fat in the liver. But it doesn’t seem to reduce the formation of scar tissue in the liver.
  • Swelling (inflammation) and sores inside the mouth (oral mucositis). Some drugs used to treat cancer can cause painful mouth sores. Early research shows that applying vitamin E to the inside of the mouth helps heal these sores and reduce pain in children.
  • Weak and brittle bones (osteoporosis). Early research shows that consuming vitamin E in the diet leads to a lower chance of hip and other fractures in adults over 40 years old.
  • Parkinson disease. People who get more vitamin E in their diet might have a lower risk of Parkinson disease. Taking supplements containing vitamin E doesn’t seem to benefit people already diagnosed with Parkinson disease.
  • A disease that causes curved, painful erections (Peyronie disease). Early research shows that adding vitamin E to regular treatment doesn’t improve pain but may reduce plaque in people with Peyronie disease.
  • Physical performance in elderly adults. Research suggests that increasing vitamin E intake in the diet is linked with improved physical performance and muscle strength in older people.
  • Breaking open (rupture) of the amniotic sac before labor begins. Some research shows that taking vitamin E throughout pregnancy does not lower the risk of having the amniotic sac break before labor begins. However, in women who have already had the amniotic sac break before labor, early research suggests that taking vitamin C and vitamin E increases time until delivery by 5 days.
  • Scarring of tissue caused by radiation therapy. Taking vitamin E by mouth with the drug pentoxifylline seems to treat scarring caused by radiation. But taking vitamin E alone doesn’t seem to be effective.
  • Kidney cancer. One small study suggests that taking vitamin E supplements is linked with a reduced risk for a certain type of kidney cancer called renal cell carcinoma.
  • A disorder that causes leg discomfort and an irresistible urge to move the legs (restless legs syndrome or RLS). Early research shows that taking vitamin E, vitamin C, separately or together, reduces the severity of RLS in people on hemodialysis.
  • Rheumatoid arthritis (RA). Vitamin E taken along with standard treatment is better than standard treatment alone for reducing pain in people with RA. But this combination doesn’t reduce swelling.
  • Stroke. There is some evidence that all-rac-alpha-tocopherol (synthetic vitamin E) might help prevent stroke in male smokers who have high blood pressure and diabetes. But not all research agrees, and some research shows that it might increase the risk for a certain type of stroke.
  • Sunburn. Taking vitamin E by mouth doesn’t seem to reduce sunburn or skin irritation.
  • Thinning of vaginal tissue (vaginal atrophy). Early research shows that inserting a vitamin E suppository into the vagina can improve symptoms of vaginal atrophy in women with breast cancer who are taking the drug tamoxifen.
  • Aging skin.
  • Chronic fatigue syndrome (CFS).
  • Depression.
  • A motor skill disorder marked by clumsiness (developmental coordination disorder or DCD).
  • Foot sores in people with diabetes.
  • Leakage of intravenous (IV) drug from the vein into the surrounding skin and tissue (extravasation).
  • Seizure disorder (epilepsy).
  • A type of non-cancerous skin sore (granuloma annulare).
  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori).
  • Long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD).
  • A group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy).
  • Recovery from laser eye surgery (photoreactive keratectomy).
  • Schizophrenia.
  • Sickle cell disease.
  • Stretch marks.
  • Swelling (inflammation) of the eye (uveitis).
  • Other conditions.

More evidence is needed to rate vitamin E for these uses.

How does it work?
Vitamin E is an important vitamin required for the proper function of many organs in the body. It is also an antioxidant. This means it helps to slow down processes that damage cells.

Is there concern for the safety of its use?
When taken by mouth: Vitamin E is LIKELY SAFE for most healthy people when taken by mouth in amounts lower than 1000 mg daily. This is the same as 1100 IU of synthetic vitamin E (all-rac-alpha-tocopherol) or 1500 IU of natural vitamin E (RRR-alpha-tocopherol). Keep in mind that the risk of side effects increases with higher doses. Side effects can include nausea, diarrhea, stomach cramps, fatigue, weakness, headache, blurred vision, rash, and bruising and bleeding. Vitamin E is POSSIBLY UNSAFE if taken by mouth in doses greater than 1000 mg daily.

When applied to the skin: Vitamin E is LIKELY SAFE for most healthy people when applied to the skin. While rare, applying vitamin E to the skin has caused itching and swelling in some people.

When inhaled: Vitamin E is POSSIBLY UNSAFE when inhaled. Use of e-cigarettes and other vaping products containing vitamin E as vitamin E acetate has been linked to serious lung injury in some people.

Special Precautions & Warnings:

Pregnancy: When used in the recommended daily amount, vitamin E is POSSIBLY SAFE for pregnant women. There has been some concern that taking vitamin E supplements might be harmful to the fetus when taken in early pregnancy. But it is too soon to know if this is an important concern. Until more is known, do not take vitamin E supplements during the first 8 weeks of pregnancy without speaking with your healthcare provider. During late pregnancy, the maximum recommended amount of vitamin E is 800 mg in women 14-18 years of age and 1000 mg in women older than 18 years of age.

Breast-feeding: Vitamin E is LIKELY SAFE when taken by mouth in recommended daily amounts during breastfeeding. The maximum recommended amount of vitamin E is 800 mg in breastfeeding women 14-18 years of age and 1000 mg in breastfeeding women older than 18 years of age. Vitamin E is POSSIBLY UNSAFE when taken in doses greater than the maximum recommended amount.

Infants and children: Vitamin E is LIKELY SAFE when taken by mouth appropriately. But children should avoid taking doses of vitamin E higher than the daily upper limits, which are 300 IU in children 1-3 years of age, 450 IU in children 4-8 years of age, 900 IU in children 9-13 years of age, and 1200 IU in children 14-18 years of age. Vitamin E (alpha-tocopherol) is POSSIBLY UNSAFE when given intravenously (by IV) to premature infants in high doses or when vitamin E is taken by mouth in doses greater than the daily upper limits.

Bleeding disorders: Vitamin E might make bleeding disorders worse. If you have a bleeding disorder, avoid taking vitamin E supplements.

Heart disease: Vitamin E might increase the risk for death in people with a history of heart disease. People with a history of heart disease should avoid taking doses of vitamin E greater than 400 IU daily.

Diabetes: Vitamin E might increase the risk for heart failure in people with diabetes. People with diabetes should avoid taking doses of vitamin E greater than 400 IU daily.

Head and neck cancer: Do not take vitamin E supplements in doses greater than 400 IU daily. Vitamin E might increase the chance that cancer will return.

Weak and brittle bones (osteoporosis): Exercise is sometimes used by people with osteoporosis to improve bone strength. Exercising and taking high doses of vitamin E and vitamin C might lessen the benefits of exercise on bone strength.

Prostate cancer: There is concern that taking vitamin E might increase the chance of developing prostate cancer. The effect of vitamin E in men who currently have prostate cancer isn’t clear. However, in theory, taking vitamin E supplements might worsen prostate cancer in men who already have it.

An inherited eye condition that causes poor night vision and loss of side vision (retinitis pigmentosa): All-rac-alpha-tocopherol (synthetic vitamin E) 400 IU seems to speed vision loss in people with retinitis pigmentosa. However, much lower amounts (3 IU) do not seem to produce this effect. If you have this condition, it is best to avoid vitamin E supplements.

Stroke: Vitamin E might increase the risk for death in some people with a history of stroke. People with a history of stroke should avoid taking doses of vitamin E greater than 400 IU daily.

Surgery: Vitamin E might increase the risk of bleeding during and after surgery. Stop using vitamin E at least 2 weeks before a scheduled surgery.

Are there any drug interactions?

Cyclosporine (Neoral, Sandimmune)

Interaction Rating=Moderate Be cautious with this combination.

Taking large amounts of vitamin E along with cyclosporine (Neoral, Sandimmune) might increase how much cyclosporine (Neoral, Sandimmune) the body absorbs. By increasing how much cyclosporine the body absorbs, vitamin E might increase the effects and side effects of cyclosporine (Neoral, Sandimmune).

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver.Vitamin E might increase how quickly the liver breaks down some medications. Taking vitamin E along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking vitamin E talk to your healthcare provider if you are taking any medications that are changed by the liver.Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications for cancer (Chemotherapy)

Interaction Rating=Moderate Be cautious with this combination.

Vitamin E is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if the interaction occurs.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Vitamin E might slow blood clotting. Taking vitamin E along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Medications used for lowering cholesterol (Statins)

Interaction Rating=Moderate Be cautious with this combination.

Taking vitamin E, beta-carotene, vitamin C, and selenium together might decrease the effectiveness of some medications used for lowering cholesterol. It is not known if taking vitamin E alone decreases the effectiveness of some medications used for lowering cholesterol.Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravachol).

Niacin

Interaction Rating=Moderate Be cautious with this combination.

Taking vitamin E along with beta-carotene, vitamin C, and selenium might decrease some of the beneficial effects of niacin. Niacin can increase the good cholesterol. Taking vitamin E along with these other vitamins might decrease the good cholesterol.

Warfarin (Coumadin)

Interaction Rating=Moderate Be cautious with this combination.

Warfarin (Coumadin) is used to slow blood clotting. Vitamin E can also slow blood clotting. Taking vitamin E along with warfarin (Coumadin) can increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Are there any interactions with herbs and supplements?
Beta-carotene: Some evidence suggests that vitamin E might reduce absorption of beta-carotene. The body needs beta-carotene to make vitamin A. Taking vitamin E 800 units daily seems to reduce blood levels of beta-carotene by 20%. Higher doses of vitamin E may reduce beta-carotene even more.
Herbs and supplements that might slow blood clotting: Vitamin E slows blood clotting. Using vitamin E along with other herbs and supplements that slow blood clotting could increase the risk of bleeding in some people. These herbs include angelica, asafoetida, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, meadowsweet, poplar, quassia, red clover, willow, and others.
Iron: There is a concern that large doses of vitamin E (>10 units/kg/day) might slow the uptake of iron supplements in severely anemic infants. Low doses of vitamin E do not seem to have this effect. Avoid high doses of vitamin E in infants. It isn’t known whether this interaction occurs in adults.
Omega-6 fatty acids: Taking omega-6 fatty acids, especially in high doses, may increase the amount of vitamin E that the body needs.
Vitamin A: Vitamin E may affect how vitamin A acts in the body.
Vitamin K: Taking doses of vitamin E of 800 IU/day or more can decrease the effects of vitamin K. This might increase the risk of bleeding in people taking warfarin or other medicines that slow blood clotting. People with low vitamin K levels might be at especially high risk.

Are there any interactions with food?
Fats and fat-containing foods: The body needs fat to be able to use vitamin E. However, it isn’t necessary to increase dietary fat to make sure vitamin E can be used by the body.

What dose is used?
The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • General: Dosing for vitamin E can be confusing. Current guidelines show recommended dietary allowances (RDA) and tolerable upper intake limits (UL) for vitamin E in milligrams (mg). But some products are still labeled in International Units (IUs). The doses of natural vitamin E (RRR-alpha-tocopherol) and vitamin E that has been made in the lab (all-rac-alpha-tocopherol) are calculated differently. This can make it difficult to figure out the correct dose.
    The daily recommended dietary allowances (RDAs) for natural vitamin E (RRR-alpha-tocopherol) in adults are 15 mg (22 IU) in men and women, 15 mg (22 IU) in pregnant women, and 19 mg (28 IU) in breastfeeding women.
  • For vitamin E deficiency: A typical dose in adults is 60-75 IU of RRR-alpha tocopherol (natural vitamin E) per day
  • For an inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED): 800-1500 mg of RRR-alpha-tocopherol or all-rac-alpha-tocopherol daily.
  • For a movement disorder often caused by antipsychotic drugs (tardive dyskinesia): 1600 IU of RRR-alpha-tocopherol (natural vitamin E) daily.
  • For improving conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility): 298-894 IU of vitamin E daily.
  • For Alzheimer disease: up to 2000 IU of vitamin E daily. Combination therapy with 5 mg of donepezil (Aricept) and 1000 IU of vitamin E per day has been used for slowing memory decline in people with Alzheimer disease.
  • For swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (non-alcoholic steatohepatitis or NASH): 800 IU of vitamin E daily.
  • For treating the reduced benefit of nitrate therapy that happens when nitrates are used all day (nitrate tolerance): 298 IU of vitamin E three times daily.
  • For an inherited disorder that causes red blood cells to break down in response to stress (G6PD deficiency): 800 IU of vitamin E daily.
  • For premenstrual syndrome (PMS): 400 IU of RRR-alpha-tocopherol (natural vitamin E) daily.
  • For menstrual cramps (dysmenorrhea): 200 IU to 500 IU of vitamin E daily starting 2 days before the menstrual period and continuing through the first 3 days of bleeding. 200 IU of vitamin E with 300 mg of fish oil has also been used.

CHILDREN

BY MOUTH:

  • General: The daily recommended dietary allowances (RDAs) for natural vitamin E (RRR-alpha-tocopherol) in children are 4 mg (6 IU) in infants 0-6 months of age, 5 mg (7 IU) in infants 7-12 months of age, 6 mg (9 IU) in children 1-3 years of age; 7 mg (10 IU) in children 4-8 years of age, 11 mg (16 IU) in children 9-13 years of age, and 15 mg (22 IU) in children 14 years and older.
  • For an inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED): 40 mg/kg of RRR-alpha-tocopherol or all-rac-alpha-tocopherol daily.
  • For a blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia): 298 mg of vitamin E daily for 4-8 weeks.
  • For treating bleeding within the skull (intracranial hemorrhage): 100 mg/kg of vitamin E (dl-alpha-tocopheryl acetate).
  • For treating bleeding into or around the fluid-filled areas (ventricles) of the brain (intraventricular hemorrhage): 29.8 IU/kg of vitamin E.
  • For swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (non-alcoholic steatohepatitis or NASH): 400-1200 IU of vitamin E daily.

By what other names is the product known?
Acétate d’Alpha Tocophérol, Acétate d’Alpha Tocophéryl, Acétate de D-Alpha-Tocophéryl, Acétate de DL-Alpha-Tocophéryl, Acétate de Tocophérol, Acétate de Tocophéryl, Acétate de Vitamine E, All Rac-Alpha-Tocopherol, All-Rac-Alpha-Tocophérol, Alpha-Tocophérol, Alpha Tocopherol Acetate, Alpha Tocopheryl Acetate, Alpha tocotrienol, Alpha tocotriénol, Alpha-tocopherol, Alpha-Tocophérol, Beta tocotrienol, Bêta-tocotriénol, Beta-tocopherol, Bêta-tocophérol, Concentré de Tocotriénol, D-Alpha Tocopherol, D-Alpha Tocophérol, D-Alpha Tocopheryl Succinate, D-Alpha Tocopheryl Acetate, D-Alpha Tocotrienol, D-Alpha Tocotriénol, D-Alpha-Tocopherol, D-Alpha-Tocophérol, D-Alpha-Tocopheryl Acetate, D-Alpha-Tocopheryl Acid Succinate, D-Alpha-Tocopheryl Succinate, D-Alpha-Tocopheryl, D-Alpha-Tocophéryl, D-Beta-Tocopherol, D-Bêta-Tocophérol, D-Delta-Tocopherol, D-Delta-Tocophérol, Delta Tocotrienol, Delta-Tocotriénol, Delta-tocopherol, Delta-tocophérol, D-Gamma Tocotrienol, D-Gamma-Tocotriénol, D-Gamma-Tocopherol, D-Gamma-Tocophérol, DL-Alpha-Tocopherol, DL-Alpha-Tocophérol, DL-Alpha-Tocopheryl Acetate, DL-Alpha-Tocopheryl, DL-Alpha-Tocophéryl, DL-Tocopherol, DL-Tocophérol, D-Tocopherol, D-Tocophérol, D-Tocopheryl Acetate, Fat-Soluble Vitamin, Gamma tocotrienol, Gamma-tocotriénol, Gamma-tocopherol, Gamma-tocophérol, Mixed Tocopherols, Mixed Tocotrienols, Palm Tocotrienols, Rice Tocotrienols, RRR-Alpha-Tocopherol, RRR-Alpha-Tocophérol, Succinate Acide de D-Alpha-Tocophéryl, Succinate Acide de Tocophéryl, Succinate de D-Alpha-Tocophéryl, Succinate de Tocophéryl, Succinate de Vitamine E, Tocopherol Acetate, Tocopherol, Tocophérol, Tocophérols Mixtes, Tocotriénols de Palme, Tocotriénols de Riz, Tocotriénols Mixtes, Tocopheryl Acetate, Tocopheryl Acid Succinate, Tocopheryl Succinate, Tocotrienol, Tocotriénol, Tocotrienol Concentrate, Tocotrienols, Tocotriénols, Vitamin E Acetate, Vitamin E Succinate, Vitamina E, Vitamine E, Vitamine Liposoluble, Vitamine Soluble dans les Graisses.

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