Emerging Areas in Research on DCIS Treatment

Read our blog, ‘It Looks Promising’: Dr. Kornelia Polyak is Uncovering New Possibilities in Breast Cancer Prevention.

DCIS (ductal carcinoma in situ) is a non-invasive breast cancer. It’s stage 0 breast cancer. Researchers are studying the best ways to treat DCIS.

Emerging areas in the treatment of DCIS include:

• Ways to predict which cases of DCIS, if left untreated, even without surgery, will progress to invasive breast cancer and which will not (to target treatment to those at higher risk)
• Determining which women may not need radiation therapy after a lumpectomy for DCIS

Avoiding radiation therapy after a lumpectomy for DCIS

Radiation therapy is a standard treatment for many people who have a lumpectomy for DCIS. It’s usually given every day, 5 days a week, for 3-4 weeks.

Radiation therapy decreases the risk of [5-12]:

• DCIS recurrence (a return of DCIS) in the treated breast
• Invasive breast cancer in the treated breast

However, overall survival is the same for women with DCIS who have a lumpectomy with or without radiation therapy [5-7].

Since radiation therapy after a lumpectomy for DCIS doesn’t improve survival, there are questions about the need for all women to get radiation therapy after a lumpectomy for DCIS.

At this time, some women may choose to omit radiation therapy after a lumpectomy when they have a low risk of DCIS recurrence or invasive breast cancer [5]. (They have small, low-grade or intermediate-grade DCIS and widely negative surgical margins, and when the DCIS is hormone receptor-positive, they usually take hormone therapy [5].)

Researchers are looking at whether other groups of women who have a lumpectomy for DCIS may also consider omitting radiation therapy.

Learn more about getting radiation therapy.

Learn about the side effects of radiation therapy.

For a summary of research studies on treatment for DCIS with a lumpectomy plus whole breast radiation therapy, visit the Breast Cancer Research Studies section.

Tumor profiling tests and radiation therapy for DCIS

Tumor profiling tests check a sample of the tumor (removed during a biopsy or surgery) for a group of genes.

The tumor profiling tests DCISionRT® and Oncotype DX Breast DCIS Score® are under study to see if they can help predict the chance that DCIS will return in the breast (as DCIS recurrence or as invasive breast cancer) [19-20]. These tests might help identify which cases of DCIS are more likely to return, which may help guide treatment [21-23].

Some findings show DCISionRT might help identify which cases of DCIS would benefit most from radiation therapy after a lumpectomy, and which women might be treated with a lumpectomy alone [24-26].

The DCISionRT and Oncotype DX Breast DCIS tests are under study.

Clinical trials

Research is ongoing to improve all areas of treatment for DCIS.

New therapies are being studied in clinical trials. The results of these studies will determine whether these therapies become part of the standard of care. Clinical trials can also study other parts of care, such as ways to manage side effects.

After discussing the benefits and risks with your oncologist, we encourage you to join a clinical trial if there’s one right for you.

Susan G. Komen® Patient Care Center

If you or a loved one needs information or resources about clinical trials, the Patient Care Center can help. Contact the Komen Breast Care Helpline at 1-877-465-6636 or email clinicaltrialinfo@komen.org. The Patient Care Center navigators offer breast cancer clinical trial education and support, such as: Knowing when to consider a trial How to find a trial How to decide which trial is best for you What to expect during a trial Information about clinical trial resources Se habla español.

BreastCancerTrials.org in collaboration with Komen offers a custom matching service to help find clinical trials that fit your health needs.

Learn what else Komen is doing to help people find and participate in breast cancer clinical trials, including trials supported by Komen.

Learn how Komen-funded research is improving treatment for breast cancer.

Learn more about clinical trials. 

Our commitment to research

At Susan G. Komen®, we are committed to saving lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer. Our Research Program is an essential driving force for achieving this mission. Since our inception in 1982, Komen has provided funding to support research grants that have greatly expanded our knowledge of breast cancer and helped us understand that breast cancer is not just a single disease but many diseases, unique to each individual. To date, Komen has provided more than $1.1 billion to researchers in 47 states, the District of Columbia, Puerto Rico and 23 countries to support research that has resulted in: A better understanding of breast cancer, including earlier detection Personalized, less invasive treatments for what was once a “one-treatment-fits-all” disease Improvements in both quality of life and survival rates Learn more about our continuing investment in research and the exciting research that we are funding, because nothing would make us happier than ending breast cancer forever.

 Updated 03/05/26

This content is regularly reviewed by an expert panel including researchers, practicing clinicians and patient advocates.