Chemotherapy for Metastatic Breast Cancer

For people with metastatic breast cancer, chemotherapy is used to kill cancer cells that have spread from the breast to other parts of the body.

Chemotherapy can increase survival and reduce symptoms related to the cancer.

Chemotherapy and metastatic breast cancer treatment

Chemotherapy is the preferred treatment for metastatic breast cancers that are:

You’ll be monitored (checked) every few months to see if the cancer is responding to treatment and if the side effects are manageable.

If the first chemotherapy drug (or combination of drugs) stops working and the cancer begins to grow again, a second or third drug can be used.

The use of each chemotherapy drug (or combination of drugs) for metastatic breast cancer is called a “line” of treatment. For example, the first chemotherapy used is called the “first-line” treatment and the second is called the “second-line” treatment.

With each line of treatment, it becomes less likely the cancer will shrink. And if the cancer does shrink, it’s often controlled for a shorter period of time with each new drug.

It’s common to get multiple lines of chemotherapy regimens (often 4 or more) over the course of treatment for metastatic breast cancer.

Learn more about how metastatic breast cancer is monitored.

Learn more about chemotherapy.

Learn about going through chemotherapy, including how chemotherapy drugs are given.

Learn more about treatment for metastatic breast cancer.

Learn about emerging areas in treatment for metastatic breast cancer.

Chemotherapy drugs commonly used to treat metastatic breast cancer

This table lists the most common chemotherapy drugs (used alone or in combination) to treat metastatic breast cancer. This list isn’t exhaustive and doesn’t include drugs rarely used or no longer in use.

Chemotherapy drugs for metastatic breast cancer

Drug (abbreviation)

Brand name

Pill or IV drug (given by vein through an IV)

Capecitabine

Xeloda

Pill

Carboplatin

Paraplatin

IV drug

Cisplatin

Platinol

IV drug

Cyclophosphamide (C)

Cytoxan

Pill or IV drug

Docetaxel (T)

Taxotere

IV drug

Doxorubicin (A)

Adriamycin

IV drug

Epirubicin (E)

Ellence

IV drug

Eribulin

Halaven

IV drug

5-Fluorouracil (5FU or F)

Adrucil

IV drug

Gemcitabine

Gemzar

IV drug

Ixabepilone

Ixempra

IV drug

Liposomal doxorubicin

Doxil

IV drug

Methotrexate (M)

Maxtrex

Pill or IV drug

Paclitaxel (T)

Taxol

IV drug

Paclitaxel, albumin bound (nab-paclitaxel)

Abraxane

IV drug

Vinorelbine

Navelbine

IV drug

Antibody-drug conjugates for metastatic breast cancer

Drug

Brand name

Pill or IV drug (given by vein through an IV)

Ado-trastuzumab emtasine (T-DM1)

Kadcyla

IV drug

Sacituzumab govitecan

Trodelvy

IV drug

Trastuzumab deruxtecan

Enhertu

IV drug

To learn more about a specific chemotherapy drug, visit the National Institutes of Health’s Medline Plus website.

Side effects of chemotherapy

Chemotherapy has many common side effects, but they vary from drug to drug.

Learn about easing worries over side effects of chemotherapy.

Learn about short-term side effects of chemotherapy.

Learn about long-term side effects of chemotherapy.

Clinical trials

Clinical trials offer the chance to try new treatments and possibly benefit from them.

Many clinical trials are available. Some are for the first treatment a person might get for their metastatic breast cancer, and others are for treatments later in the disease course. Consider joining a clinical trial when you’re newly diagnosed, when your oncologist is considering changing treatments or when there are limited treatment options.

Susan G. Komen® Breast Care Helpline

If you or a loved one needs information or resources about clinical trials, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org.

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Metastatic Trial Search

The Metastatic Trial Search is a web-based clinical trial matching tool that can help you find clinical trials that fit your needs.

Learn more about clinical trials for people with metastatic breast cancer.

Learn what Komen is doing to help people find and participate in breast cancer clinical trials, including trials supported by Komen.

Financial assistance

Costs related to metastatic breast cancer care can quickly become a financial burden. Dealing with finances and insurance can be overwhelming.

Many cancer centers have patient financial counselors who can discuss insurance and cost coverage with you.

Learn about insurance plans and prescription drug assistance programs.

Learn about other financial assistance programs.

Komen Financial Assistance Program

Susan G. Komen® created the Komen Financial Assistance Program to help those struggling with the costs of breast cancer treatment by providing financial assistance to eligible individuals.

Funding is available for eligible individuals undergoing breast cancer treatment at any stage or living with metastatic breast cancer (stage 4).

To learn more about this program and other helpful resources, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org.

Se habla español.

Susan G. Komen®‘s position on fairness in oral cancer drug coverage

Insurance coverage of oral cancer drugs

Cancer medications given by vein (through an IV) or injection (under the skin or into a muscle) are usually covered under a health insurance plan’s medical benefit. However, cancer medications that are pills (oral cancer drugs) are usually covered under a health insurance plan’s prescription drug benefit.

As a result, people often find themselves facing high out-of-pocket costs when filling prescriptions for oral cancer drugs. Sometimes these costs can be thousands of dollars a month.

The impact of high cost-sharing

High prescription drug costs and the resulting out-of-pocket burden on patients are a barrier to care. They can prevent people from getting the medications prescribed by their health care providers.

No one should be forced to get less appropriate treatment because an insurer gives more coverage for IV and injectable drugs than pills.

Efforts to increase fairness in drug coverage

Komen supports state and federal efforts to require insurers to provide the same or better coverage for oral cancer drugs as they do for IV and injectable cancer drugs. This would help make sure patients have access to affordable, appropriate treatment.

Become a Komen Advocacy Insider

Sign up to be a Komen Advocacy Insider and get informed when action is needed on drug coverage issues at the state or national level.

SUSAN G. KOMEN® METASTATIC BREAST CANCER SUPPORT RESOURCES

  • If you or a loved one needs more information about metastatic breast cancer, contact the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org. All calls are answered by a trained specialist or oncology social worker, Monday through Friday from 9:00 a.m. to 10:00 p.m. ET. Se habla español.
  • Komen Patient Navigators can help guide you through the health care system as you go through a metastatic breast cancer diagnosis and treatment. They can help to remove barriers to high-quality breast care. For example, they can help you with insurance, local resources, communication with health care providers and more. Call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org to learn more about our Patient Navigator program, including eligibility.
  • We offer an online support community through our closed Komen Metastatic Breast Cancer (Stage IV) Group. The Facebook group provides a place where those living with metastatic breast cancer, and those who love them, can find support, friendship and information. Click the link above or visit Facebook and search for Komen Metastatic Breast Cancer (Stage IV) Group and request to join.
  • Our free MBC Impact Series provides people living with metastatic breast cancer and their loved ones a safe, collaborative space to gather information related to metastatic breast cancer and discover practical resources to help make decisions for improved physical and emotional health. To learn more and register visit www.komen.org/mbcseries.
  • Our Real Pink podcast series covers many relevant topics for people living with metastatic breast cancer and caregivers.
  • Our fact sheets, booklets and other education materials offer additional information.

Updated 06/25/23

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