Chemotherapy for Metastatic Breast Cancer
For people with metastatic breast cancer, chemotherapy is used to kill cancer cells that have spread from the breast to other parts of the body.
Chemotherapy can increase survival and reduce symptoms related to the cancer.
Chemotherapy and metastatic breast cancer treatment
Chemotherapy is the preferred treatment for metastatic breast cancers that are:
- Hormone receptor-negative
- Hormone receptor-positive, but no longer respond to hormone therapy
- HER2-positive (in combination with HER2-targeted therapy)
You’ll be monitored (checked) every few months to see if the cancer is responding to treatment and if the side effects are manageable.
If the first chemotherapy drug (or combination of drugs) stops working and the cancer begins to grow again, a second or third drug can be used.
The use of each chemotherapy drug (or combination of drugs) for metastatic breast cancer is called a “line” of treatment. For example, the first chemotherapy used is called the “first-line” treatment and the second is called the “second-line” treatment.
With each line of treatment, it becomes less likely the cancer will shrink. And if the cancer does shrink, it’s often controlled for a shorter period of time with each new drug.
It’s common to get multiple lines of chemotherapy regimens (often 4 or more) over the course of treatment for metastatic breast cancer.
Learn more about how metastatic breast cancer is monitored.
Learn more about chemotherapy.
Learn about going through chemotherapy, including how chemotherapy drugs are given.
Learn more about treatment for metastatic breast cancer.
Learn about emerging areas in treatment for metastatic breast cancer.
Chemotherapy drugs commonly used to treat metastatic breast cancer
This table lists the most common chemotherapy drugs (used alone or in combination) to treat metastatic breast cancer. This list isn’t exhaustive and doesn’t include drugs rarely used or no longer in use.
Chemotherapy drugs for metastatic breast cancer | ||
Drug (abbreviation) | Brand name | Pill or IV drug (given by vein through an IV) |
Capecitabine | Xeloda | Pill |
Carboplatin | Paraplatin | IV drug |
Cisplatin | Platinol | IV drug |
Cyclophosphamide (C) | Cytoxan | Pill or IV drug |
Docetaxel (T) | Taxotere | IV drug |
Doxorubicin (A) | Adriamycin | IV drug |
Epirubicin (E) | Ellence | IV drug |
Eribulin | Halaven | IV drug |
5-Fluorouracil (5FU or F) | Adrucil | IV drug |
Gemcitabine | Gemzar | IV drug |
Ixabepilone | Ixempra | IV drug |
Liposomal doxorubicin | Doxil | IV drug |
Methotrexate (M) | Maxtrex | Pill or IV drug |
Paclitaxel (T) | Taxol | IV drug |
Paclitaxel, albumin bound (nab-paclitaxel) | Abraxane | IV drug |
Vinorelbine | Navelbine | IV drug |
Antibody-drug conjugates for metastatic breast cancer | ||
Drug |
Brand name |
Pill or IV drug (given by vein through an IV) |
Kadcyla |
IV drug |
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Trodelvy |
IV drug |
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Enhertu |
IV drug |
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To learn more about a specific chemotherapy drug, visit the National Institutes of Health’s Medline Plus website.
Side effects of chemotherapy
Chemotherapy has many common side effects, but they vary from drug to drug.
Learn about easing worries over side effects of chemotherapy.
Learn about short-term side effects of chemotherapy.
Learn about long-term side effects of chemotherapy.
Clinical trials
Clinical trials offer the chance to try new treatments and possibly benefit from them.
Many clinical trials are available. Some are for the first treatment a person might get for their metastatic breast cancer, and others are for treatments later in the disease course. Consider joining a clinical trial when you’re newly diagnosed, when your oncologist is considering changing treatments or when there are limited treatment options.
Susan G. Komen® Breast Care Helpline |
If you or a loved one needs information or resources about clinical trials, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org. Se habla español. |
Metastatic Trial Search |
The Metastatic Trial Search is a web-based clinical trial matching tool that can help you find clinical trials that fit your needs. |
Learn more about clinical trials for people with metastatic breast cancer.
Financial assistance
Costs related to metastatic breast cancer care can quickly become a financial burden. Dealing with finances and insurance can be overwhelming.
Many cancer centers have patient financial counselors who can discuss insurance and cost coverage with you.
Learn about insurance plans and prescription drug assistance programs.
Learn about other financial assistance programs.
Komen Financial Assistance Program |
Susan G. Komen® created the Komen Financial Assistance Program to help those struggling with the costs of breast cancer treatment by providing financial assistance to eligible individuals. Funding is available for eligible individuals undergoing breast cancer treatment at any stage or living with metastatic breast cancer (stage 4). To learn more about this program and other helpful resources, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org. Se habla español. |
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Susan G. Komen®‘s position on fairness in oral cancer drug coverage |
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Insurance coverage of oral cancer drugs Cancer medications given by vein (through an IV) or injection (under the skin or into a muscle) are usually covered under a health insurance plan’s medical benefit. However, cancer medications that are pills (oral cancer drugs) are usually covered under a health insurance plan’s prescription drug benefit. As a result, people often find themselves facing high out-of-pocket costs when filling prescriptions for oral cancer drugs. Sometimes these costs can be thousands of dollars a month. The impact of high cost-sharing High prescription drug costs and the resulting out-of-pocket burden on patients are a barrier to care. They can prevent people from getting the medications prescribed by their health care providers. No one should be forced to get less appropriate treatment because an insurer gives more coverage for IV and injectable drugs than pills. Efforts to increase fairness in drug coverage Komen supports state and federal efforts to require insurers to provide the same or better coverage for oral cancer drugs as they do for IV and injectable cancer drugs. This would help make sure patients have access to affordable, appropriate treatment. Become a Komen Advocacy Insider Sign up to be a Komen Advocacy Insider and get informed when action is needed on drug coverage issues at the state or national level. |
SUSAN G. KOMEN® METASTATIC BREAST CANCER SUPPORT RESOURCES |
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Updated 06/25/23
