Trop-2 Antibody-Drug Conjugates for Metastatic Breast Cancer

What are antibody-drug conjugates?

Special antibody drugs are designed to target certain cancer cells. Antibody-drug conjugates are a combination of an antibody therapy and a chemotherapy drug. Combining these into one drug allows the targeted delivery of the chemotherapy to specific cancer cells.

What are Trop-2 antibody-drug conjugates?

Some breast cancers have cells that express the protein Trop-2. Triple negative breast cancers tend to express Trop-2.

Sacituzumab govitecan (Trodelvy) is a Trop-2 antibody-drug conjugate. It combines a Trop-2 antibody and the chemotherapy drug SN-38. This combination allows the targeted delivery of SN-38 to cancer cells that express Trop-2.

Sacituzumab govitecan (Trodelvy) and metastatic breast cancer treatment

Sacituzumab govitecan is FDA-approved for the treatment of metastatic triple negative breast cancers that have already been treated with at least 2 drug therapies (at least one in the metastatic setting).

Study findings have shown sacituzumab govitecan helps shrink tumors in women with metastatic triple negative breast cancers and may improve survival [53-54].

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For a summary of research studies on sacituzumab govitecan and metastatic breast cancer treatment, visit the Breast Cancer Research Studies section.

Learn more about treatment for metastatic breast cancer.

Learn about emerging areas in the treatment for metastatic breast cancer.

Learn more about triple negative breast cancer.

How is sacituzumab govitecan given?

Sacituzumab govitecan is given by vein (through an IV).

Side effects of sacituzumab govitecan

Side Effects

Sacituzumab govitecan

Possible side effects include diarrhea, nausea, vomiting, fatigue, anemia (low red blood cell counts), hair loss, constipation and rash.

Sacituzumab govitecan increases the risk of having a low white blood cell count. Your blood cell counts will be monitored while taking sacituzumab govitecan.

Adapted from select sources [54-55].

Monitoring metastatic breast cancer

You’ll be monitored (checked) regularly with scans to see if the cancer is responding to treatment. If it’s no longer working, or if the side effects are not manageable, your health care provider will change your treatment.

Learn more about how metastatic breast cancer is monitored.

Clinical trials

Clinical trials offer the chance to try new treatments and possibly benefit from them.

Consider joining a clinical trial when your oncologist is considering changing treatments, before starting a new treatment or when there are limited treatment options.

Susan G. Komen® Breast Care Helpline

If you or a loved one needs information or resources about clinical trials, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org.

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Metastatic Trial Search

The Metastatic Trial Search is a web-based clinical trial matching tool that can help you find clinical trials that fit your needs.

Learn more about clinical trials for people with metastatic breast cancer.

Prescription drug assistance

The cost of drug therapies for metastatic breast cancer can quickly become a financial burden for you and your family.

Medicare and many insurance companies offer prescription drug plans. One may already be included in your policy, or you may be able to buy an extra plan for prescriptions.

Some drugs are off-patent and may have a generic form. Generic drugs cost less than the name brands but are just as effective.

You may also qualify for programs that help with drug costs or offer low-cost or free prescriptions.

Learn more about insurance plans and prescription drug assistance programs.

Learn more about other financial assistance programs.

Komen Financial Assistance Program

Susan G. Komen® created the Komen Financial Assistance Program to help those struggling with the costs of breast cancer treatment by providing financial assistance to eligible individuals.

Funding is available for eligible individuals undergoing breast cancer treatment at any stage or living with metastatic breast cancer (stage IV).

To learn more about this program and other helpful resources, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org.

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SUSAN G. KOMEN® SUPPORT RESOURCES

  • If you or a loved one needs more information about breast health or breast cancer, contact the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org. All calls are answered by a trained specialist or oncology social worker, Monday through Friday from 9:00 a.m. to 10:00 p.m. ET. Se habla español.
  • Komen Patient Navigators can help guide you through the health care system as you go through a breast cancer diagnosis. They can help to remove barriers to high-quality breast care. For example, they can help you with insurance, local resources, communication with health care providers and more. Call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org to learn more about our Patient Navigator program, including eligibility.
  • We offer an online support community through our closed Komen Metastatic Breast Cancer group. The Facebook group provides a place where those living with metastatic breast cancer, and those who love them, can find support, friendship and information. Visit Facebook, search for Komen Metastatic Breast Cancer (Stage IV) Group and request to join the closed group.
  • Our free MBC Impact Series provides people living with metastatic breast cancer and their loved ones a safe, collaborative space to gather information related to MBC and discover practical resources to help make decisions for improved physical and emotional health. To learn more and register visit www.komen.org/mbcseries.
  • Our podcast series Real Pink covers many relevant topics for people living with metastatic breast cancer and caregivers.
  • Our fact sheets, booklets and other education materials offer additional information.
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Komen Perspectives

Read our perspective on metastatic breast cancer.*

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*Please note, the information provided within Komen Perspectives articles is only current as of the date of posting. Therefore, some information may be out of date.

Updated 10/05/22

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