PARP Inhibitors for Metastatic Breast Cancer
What are PARP inhibitors?
Olaparib (Lynparza) and talazoparib (Talzenna) are poly(ADP-ribose) polymerase (PARP) inhibitors.
PARP is an enzyme involved in DNA repair. Some chemotherapy drugs damage tumor DNA. PARP inhibitors work to stop PARP from repairing tumor DNA. This can help the chemotherapy kill the cancer cells.
The PARP inhibitors FDA-approved for metastatic breast cancer treatment are:
Drug name |
Brand name |
How is it given? |
Olaparib |
Lynparza |
Pill |
Talazoparib |
Talzenna |
Pill |
PARP inhibitors and BRCA1 and BRCA2 inherited gene mutations
PARP inhibitors are only used to treat breast cancers in people who have a BRCA1 or BRCA2 (BRCA1/2) inherited gene mutation.
BRCA1/2-related breast cancers have problems repairing tumor DNA. These breast cancers seem to be sensitive to DNA damage caused by PARP inhibitors. Treating BRCA1/2-related breast cancers with a PARP inhibitor makes it even harder for the breast cancer to repair itself, leading to tumor cell death.
The National Comprehensive Cancer Network (NCCN) recommends everyone diagnosed with metastatic breast cancer get BRCA1/2 genetic testing to see if a PARP inhibitor can be used for treatment [4]. This recommendation includes patients who don’t have a family history of breast cancer [4].
Learn about genetic testing to guide breast cancer treatment.
Learn more about BRCA1/2 inherited gene mutations.
PARP inhibitors and metastatic breast cancer treatment
Olaparib and talazoparib are used to treat HER2-negative metastatic breast cancer in people who have a BRCA1 and BRCA2 (BRCA1/2) inherited gene mutation and have been treated with chemotherapy at least once in the past (including chemotherapy for early breast cancer).
If the metastatic breast cancer is hormone receptor-positive, people should have also been treated with hormone therapy in the metastatic setting at least once in the past. (Hormone therapy is usually the first treatment for hormone receptor-positive metastatic breast cancer.)
Compared to chemotherapy alone, chemotherapy plus olaparib or talazoparib may give women with a BRCA1/2 inherited gene mutation who have HER2-negative metastatic breast cancer more time before the cancer worsens [54-55].
| For a summary of research studies on PARP inhibitors and metastatic breast cancer treatment, visit the Breast Cancer Research Studies section. |
Learn more about treatment for metastatic breast cancer.
Learn more about emerging areas in treatment for metastatic breast cancer.
Learn about the PARP inhibitor olaparib in the treatment of early breast cancer.
How are PARP inhibitors given?
The PARP inhibitors olaparib and talazoparib are pills.
Side effects of PARP inhibitors
Although they have side effects, PARP inhibitors are often easier to tolerate than chemotherapy drugs.
PARP Inhibitor |
Side Effects |
Olaparib |
Possible side effects include anemia (low red blood cell counts), low white blood cell counts, nausea, vomiting and fatigue. In rare cases, it can cause acute myeloid leukemia. |
Talazoparib |
Possible side effects include fatigue, anemia (low red blood cell counts), nausea, vomiting, headache and diarrhea. In rare cases, it can cause acute myeloid leukemia. |
Adapted from select sources [54-57]. |
|
Before you begin taking olaparib or talazoparib, talk with your health care provider about possible side effects and how to manage them.
Monitoring metastatic breast cancer
You’ll be monitored (checked) regularly with scans to see if the cancer is responding to treatment. If it’s no longer working, or if the side effects are not manageable, your health care provider will change your treatment or discuss other options.
Learn more about how metastatic breast cancer is monitored.
Clinical trials
Clinical trials offer the chance to try new treatments and possibly benefit from them.
Many clinical trials are available. Some are for the first treatment a person might get for their metastatic breast cancer, and others are for treatments later in the disease course. Consider joining a clinical trial when you’re newly diagnosed, when your oncologist is considering changing treatments or when there are limited treatment options.
Susan G. Komen® Breast Care Helpline |
If you or a loved one needs information or resources about clinical trials, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org. Se habla español. |
Metastatic Trial Search |
The Metastatic Trial Search is a web-based clinical trial matching tool that can help you find clinical trials that fit your needs. |
Learn more about clinical trials for people with metastatic breast cancer.
Prescription drug assistance
The cost of drug therapies for metastatic breast cancer can quickly become a financial burden for you and your family.
Medicare and many insurance companies offer prescription drug plans. One may already be included in your policy, or you may be able to buy an extra plan for prescriptions.
You may also qualify for programs that help with drug costs or offer low-cost or free prescriptions.
Many cancer centers have patient financial counselors who can discuss insurance and cost coverage with you.
Learn more about insurance plans and prescription drug assistance programs.
Learn more about other financial assistance programs.
Komen Financial Assistance Program |
Susan G. Komen® created the Komen Financial Assistance Program to help those struggling with the costs of breast cancer treatment by providing financial assistance to eligible individuals. Funding is available for eligible individuals undergoing breast cancer treatment at any stage or living with metastatic breast cancer (stage 4). To learn more about this program and other helpful resources, call the Komen Breast Care Helpline at 1-877 GO KOMEN (1-877-465-6636) or email helpline@komen.org. Se habla español. |
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Susan G. Komen®‘s position on fairness in oral cancer drug coverage |
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Insurance coverage of oral cancer drugs Cancer medications given by vein (through an IV) or injection (under the skin or into a muscle) are usually covered under a health insurance plan’s medical benefit. However, cancer medications that are pills (oral cancer drugs) are usually covered under a health insurance plan’s prescription drug benefit. As a result, people often find themselves facing high out-of-pocket costs when filling prescriptions for oral cancer drugs. Sometimes these costs can be thousands of dollars a month. The impact of high cost-sharing High prescription drug costs and the resulting out-of-pocket burden on patients are a barrier to care. They can prevent people from getting the medications prescribed by their health care providers. No one should be forced to get less appropriate treatment because an insurer gives more coverage for IV and injectable drugs than pills. Efforts to increase fairness in drug coverage Komen supports state and federal efforts to require insurers to provide the same or better coverage for oral cancer drugs as they do for IV and injectable cancer drugs. This would help make sure patients have access to affordable, appropriate treatment. Become a Komen Advocacy Insider Sign up to be a Komen Advocacy Insider and get informed when action is needed on drug coverage issues at the state or national level. |
SUSAN G. KOMEN® METASTATIC BREAST CANCER SUPPORT RESOURCES |
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Updated 06/23/23
