Breast Cancer 101
A Guide to Breast Cancer by Susan G. Komen
CHAPTER 6
Breast Cancer Diagnosis
CHAPTER 6
Breast Cancer Diagnosis
Chapter Overview
Breast Cancer Diagnosis discusses the different types of biopsies, how they are performed and how a diagnosis is made. It also discusses how the tissue specimen from a biopsy is handled and preserved.
Also included are various types of breast cancer, tumor characteristics and how breast cancer is staged. The traditional TNM staging system is reviewed.
This chapter also reviews pathology reports and how to interpret the information contained within them.
The following topics are discussed in this section:
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Breast Cancer Diagnosis Overview
- Tests to diagnose breast cancer
- When a biopsy is required
- Learning about the diagnosis
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Breast Biopsies
- Core needle biopsy
- Fine needle aspiration (FNA)
- Surgical biopsy
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Preserving Tissue Samples
- Fixed paraffin preservation
- Frozen tissue preservation
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Introduction to Types and Stages of Breast Cancer
- Different types of breast cancer
- Microscopic characteristics
- Ductal and lobular cancers
- Other breast cancers
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Non-Invasive and Invasive Breast Cancers
- Non-invasive breast cancer (DCIS)
- Invasive breast cancer
- Invasive ductal carcinoma
- Invasive lobular carcinoma
- Metastasis
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Less Common Invasive Breast Cancers and Paget Disease of the Breast
- Inflammatory breast cancer (IBC)
- Metaplastic breast cancer
- Triple negative breast cancer
- Paget disease of the breast
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Factors that Affect Prognosis and Treatment
- Hormone receptor and HER2 status
- Tumor grade
- Breast cancer staging
- Stages of breast cancer
- TNM staging
- Tumor profiling
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Lymph Node Status
- Sentinel node biopsy
- Axillary lymph node dissection
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Pathology Reports
- The analysis and reporting process
- Terminology of pathology reports
- Use of a pathology report
- Reviewing reports
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Contents of a Pathology Report
- Diagnosis
- Hormone receptor status
- HER2 status
- Tumor size, type and grade
- Invasive vs. non-invasive
- Lymph node status
- Patient information
- Clinical history
- Tumor location
- Specimen information
- Procedure description
- Gross description
- Optional information
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Pathology Report after Neoadjuvant Therapy
- Prognostic vs. pathological stage
- TNM Staging
- Tumor size
- Lymph node status
- Response to neoadjuvant therapy
