Breast Cancer 101
A Guide to Breast Cancer by Susan G. Komen
CHAPTER 12
HER2-Targeted Therapy
CHAPTER 12
HER2-Targeted Therapy
Chapter Overview
HER2-Targeted Therapy discusses a class of drugs that target specific molecular pathways to fight cancer.
This chapter discusses targeted therapies and examines the individual drugs that are being used to treat breast cancer.
The following topics are discussed in this section:
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HER2-Targeted Therapies for Early Breast Cancer
- HER2 protein expression
- Prevalence of HER2 positive breast cancers
- HER2-targeted therapies
-
Trastuzumab
- How trastuzumab works
- Benefits of trastuzumab
- Trastuzumab administration
- Potential risks of trastuzumab
- Biosimilar forms of trastuzumab
- Ado-trastuzumab emtansine
- Possible side effects of Ado-trasutzumab
-
Pertuzumab
- How pertuzumab works
- Benefits of pertuzumab
- Pertuzumab administration
- Possible side effects of pertuzumab
- Use in treatment of metastatic breast cancer
-
Neratinib
- How neratinib works
- Indications for neratinib
- Possible side effects of neratinib
- Use in treatment of metastatic breast cancer
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CDK4/6 Inhibitors
- CDK 4/6 enzymes and inhibitors
- Abemaciclib
- Indications for abemaciclib
- Benefits of abemaciclib
- Possible side effects of abemaciclib
- Use in treatment of metastatic breast cancer
-
Immunotherapy
- How Immunotherapy works
- Pembrolizumab
- Indications for pembrolizumab
- Pembrolizumab regimens and administration
- Possible side effects of pembrolizumab
- Use in treating triple negative and metastatic breast cancer
-
PARP Inhibitors
- PARP enzyme and inhibitors
- How PARP inhibitors work
- Olaparib
- Indication for olaparib
- Possible side effects of olaparib
- Use in treatment of metastatic breast cancer
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Tumor Profiling
- How tumor profiling works
- Purpose of tumor profiling
- Approved tumor profiling tools
- Oncotype DX®